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In a double-blind trial in severe low back pain with a neuropathic component, tapentadol PR tapentadol 500 mg was associated with comparable improvements in pain intensity to a combination of tapentadol PR 300 mg/pregabalin 300 mg, with improved central nervous system tolerability in the monotherapy arm but overall a favorable tolerability profile also for the combination (Baron et al, A further trial in diabetic peripheral neuropathic pain (Vinik et al .

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